I.C. Gunsalus Professor
Dept of Biochemistry
Dept of Chemistry
College of Medicine
Center for Biophysics and Computational Biology
Director, School of Molecular and Cellular Biology
| Sligar Lab | Stephen G. Sligar I.C. Gunsalus Professor Dept of Biochemistry Dept of Chemistry College of Medicine Center for Biophysics and Computational Biology Director, School of Molecular and Cellular Biology |
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A current and full publication list is available as a PDF download (June 2008) [get a free Adobe Reader]
Last three years (2006-2008):
REVIEWED PAPERS
248. Heng, J. B., Aksimentiev, A., Ho, C., Grinkova, Y. V., Sligar, S. G., Schulten, K., and Gimp, G. (2006) "The Electromechanics of DNA in a Synthetic Nanopore." Biphysical Journal, 90, 1098-1106.
249. Makris, T. M., von Koenig, K., Schlichting, I. and Sligar, S. G. (2006) "The Status of High-Valent Metal Oxo Complaexes in the P450 Cytochromes." J. Inorganic Biochemistry, 100, 507-518.
250. Leitz, A. J., Bayburt, T. H., Barnakov, A. N., Springer, B. A., and Sligar, S. G. (2006) "Functional Reconstitution of ß2-Adrenergic Receptors Utilizing Self-Assembling Nanodisc Technology." BioTechniques, 40, 601-610.
251. Denisov, I. G., Grinkova, Y. V., Baas, B. J., and Sligar, S. G. (2006) "The Ferrous-Dioxygen Intermediate in Human Cytochrome P450 3A4: Substrate Dependence of Formation and Decay Kinetics." J. Biol. Chem, 281, 23313-23318.
252. Bayburt, T. H., Grinkova, Y. V., and Sligar, S. G., (2006) "Assembly of Single Bacteroirhodopsin Trimers in Bilayer Nanodiscs." Archives Biochemistry and Biophysics, 450, 215-222.
253. Newcomb. M., Zhang, R., Chandrasena, R.E.P., Halgrimson, J. A., Horner, J. H., Makris, T. M., and Sligar, S. G. (2006) "Cytochrome P450 Compound l." J. American Chemical Society 128, 4580-4581.
254. Boldog, T., Grimme, S., Li, M., Sligar, S. G., and Hazelbauer, G. L. (2006) "Nanodiscs Separate Chemoreceptor Oligomeric States and Reveal Their Signaling Properties." Proceedings of the National Academy of Sciences 103, 11509-11514.
255. Zhao, J., Das, A., Zhang, X., Schatz, G. C., Sligar, S. G., and Van Duyne, R. P. (2006) "Resonance Surface Plasmon Spectroscopy: Low molecular Weight Substrate Binding to Cytochrome P450." J. A. Chem. Soc. 128, 11004-11005.
256. Li, Y., Kijac, A. Z., Sligar, S. G., and Rienstra, C. M. (2006) "Structural Analysis of Nanoscale Self-Assembled Discoidal Lipid Bilayers by Solid-State NMR Spectroscopy." Biophys. J. 91, 3819-3828.
257. Shaw, A.W., Pureza, V.S., Sligar, S.G., and Morrissey, J.H. (2007) "The Local Phospholipid Environment Modulates the Activation of Blood Clotting." J. Biological Chemistry, 282, 6556-6563.
258. Denisov, I.G., Victoria, D.C., Sligar, S.G. (2007) "Cryoradiolytic Reduction of Heme Proteins: Maximizing Dose-Dependent Yield." Radiation Physics and Chemistry 76, 714-721.
259. Denisov, I.G., Baas, B.J., Grinkova, Y.V., and Sligar, S. G. (2007) "Cooperativity in P450 CYP3A4: Linkages in Substrate Binding, Spin State, Uncoupling and Product Formation." J. Biological Chemistry 282, 7066-7076.
260. Nath, A., Atkins, W. M., and Sligar, S. G. (2007) "Applications of Phospholipid Bilayer Nanodiscs in the Study of Membranes and Membrane Proteins." Biochemistry 46, 2059-2069.
261. Alami, M., Dalal, K., Lelj-Garolla, B., Sligar, S. G., and Duong, F. (2007) "Nanodiscs Unravel the Interaction Between the SecYEG Channel and it's Cytosolic Partner SecA." The EMBO Journal, 26, 1995-2004.
262. Chougnet, A., Grinkova, Y., Ricard, D., Sligar, S., and Woggon, W-D (2007) "Fluorescent Probes for Raid Screening of Potential Drug-Drug Interactions at the CYP3A4 Level." ChemMedChem, 2, 717-724.
263. Bayburt, T.H., Leitz, A.J., Xie, G., Oprian, D.D., and Sligar, S.G. (2007) "Transducin Activation by Nanoscale Lipid Bilayers Containing One and Two Rhodopsins." J. Biological Chemistry, 282, 14875-14881.
264. Shih, A. Y., Freddolino, P. L., Sligar, S. G. and Schulten, K. (2007) "Disassembly of Nanodiscs with Cholate" NanoLetters, 7, 1692-1696.
265. Zhao, Q., Sigalov, G., Dimitrov, V., Dorvel, B., Mirsaidov, U., Sligar, S., Aksimentiev, A. and Timp, G. (2007) "Detecting SNPs Using a Synthetic Nanopore" NanoLetters, 7, 1680-1685.
266. Mak, P.J., Denisov, I.G., Victoria, D., Makris, T.M., Deng, T., Sligar, S.G., and Kincaid, J.R. (2007) "Resonance Raman Detection of the Hydroperoxo Intermediate in the Cytochrome P450 Enzymatic Cycle." J. American Chemical Society, 129, 6382-6383.
267. Nath, A., Grinkova, Y.V., Sligar, S. G., and Atkins, W. M. (2007) "Ligand Binding to Cytochrome P450 3A4 in Phospholipid Bilayer Nanodiscs: The Effect of Model Membranes." J Biological Chemistry, 282, 28309-28320.
268. Kimmich, N., Das, A., Sevrioukova, I., Meharenna, Y., Sligar, S. G., and Poulos, T. L. (2007) "Electron Transfer Between Cytochrome P450CIN and It's FMN-Containing Redox Partner, Cindoxin." J. Biological Chemistry, 37, 27006-27011
269. Denisov, I.G., Grinkova, Y.V., McLean, M.A., and Sligar, S. G. (2007) "The One Electron Autoxidatiaon of Human Cytochrome P4503A4." J. Biological Chemistry, 37, 26865-26873.
270. Sligar, S. G., and Denisov. I. G. (2007) "Understanding Cooperativity in Human P450 Mediated Drug-Drug Interactions." Drug Metabolism Reviews, 39, 567-579.
271. Shih, A.Y., Arkhipov, A., Freddolino, P.L., Sligar, S.G. and Schulten, K. (2007) "Assembly of Lipids and Proteins into Lipoprotein Particles." J Phys Chem B, 38, 11095-11104.
272. Denisov, I.G., Dawson, J.H., Hager, L.P., and Sligar, S.G. (2007) "The Ferric-Hydroperoxo Complex of Chloroperoxidase." Archives Biochemistry and Biophysics, 363, 954-958.
273. Das, A., Grinkova, Y.V., and Sligar, S.G. (2007) "Redox Potential Control by Drug Binding to Cytochrome P450 3A4." J. American Chemical Society, 129, 13778-13779.
274. Kijac, A.Z., Li, Y., Sligar, S.G., and Rienstra, C.M. (2007) "Magic-Angle Spinning Solid-State NMR Spectroscopy of Nanodisc-Embedded Human CYP3A4." Biochemistry, 46, 13696-13703.
275. Marin, V. L., Bayburt, T. H., Sligar, S. G., and Mrksich, M. (2007) "Functional Assays of Membrane-Bound Proteins with SAMDI-TOF Mass Spectrometry." Angew. Chem, Int. Ed, 46, 8796-8798.
276. Davydov, D.R., Baas, B.J., Sligar, S.G., Haplert, J.R. (2007) "Allosteric Mechanisms in Cytochrome P450 3A4 Studied by High-Pressure Spectroscopy: Pivotal Role of Substrate-Induced Changes in the Accessibility and Degree of Hydration of the Heme Pocket." Biochemistry, 46, 7852-7864.
277. Makris, T.M., vonKoenig, J., Schlichting, I., Sligar, S.G. (2007) "Alteration of P450 Distal Pocket Solvent Leads to Impaired Proton Delivery and Changes in Heme Geometry." Biochemistry, 46, 14129-14140.
278. Hall, B., McLean, M. A., Davis, K., Casanova, J. E., Sligar, S. G., and Schwartz, M. A. (2008) "A Fluorescence Resonance Energy Transfer Activation Sensor for Arf6." Analytical Biochemistry, 374, 243-249.
279. Newcomb, M., Halgrimson, J.A., Horner, J.H., Wasinger, E.C., Chen, L.X., and Sligar, S.G. (2008) "X-Ray Absorption Spectroscopic Characterization of a Cytochrome P450 Compound II Derivative." Proceedings of the National Academy of Sciences, 24, 8179-8184.
280. Shih, A.Y., Sligar, S.G., and Schulten, K. (2008) "Molecular Models Need to be Tested: The Case of the Solar Flares Discoidal HDL Model." Biophysical Journal, 94, L87-L89.
281. Gruia, F., Ionascu, D., Kubo, M., Ye, X., Dawson, J., Osborne, R.L., Sligar, S.G., Denisov, I., Poulos, T.L., Terner, J., and Champion, P.M. (2008) "Low Frequency Dynamics of Caldariomyces fumago Chloroperoxidase Probed by Femtosecond Coherence Spectroscopy." Biochemistry, 47, 5156-5167.
282. Morrissey, J. H., Pureza, V., Davis-Harrison, R. L., Sligar, S. G., Ohkubo, Y. Z. and Tajkhorshid, E. (2008) "Blood Clotting Reactions on Nanoscale Phospholipid Bilayers." Thrombosis Research, In Press.
283. Grinkova, Y.V., Denisov, I. G., Waterman, M. R.., Arase, M., Kagawa, N., and Sligar, S. G. (2008) "The Ferrous-Oxy Complex of Human Aromatase." Biochem Biophys Res Comm, 372, 379-382.
284. Kuhnel, K., Ke, N., Cryle, M. J., Sligar, S. G., Schuler, M. A., and Schlichting, I (2008) "Crystal Structures of Substrate-Free and Retinoic Acid-Bound Cyanobacterial Cytochrome P450 CYP120A1." Biochemistry, May 31, on-line.
